Scientific Assurance of Immunological Compatibility in Transplantation

Tissue Typing and Transplantation Immunology is a highly specialized laboratory discipline that evaluates immunological compatibility between donor and recipient in cell, tissue, and organ transplantation. Transplant success largely depends on the accurate and reliable determination of this compatibility.

Our laboratory plays a critical role in bone marrow (hematopoietic stem cell) transplantation and in the diagnosis and follow-up of hematologic malignancies and primary immunodeficiency disorders. With modern infrastructure and an experienced team, we provide comprehensive scientific support to clinical departments.

What Is HLA (Human Leukocyte Antigen) Typing?

The Most Critical Step in Transplantation

The HLA system is a fundamental component of the immune system, enabling the distinction between “self” and “non-self.” Evaluating HLA compatibility prior to transplantation is essential for preventing rejection and ensuring long-term success.

HLA tissue typing is performed for:

The recipient
Family members
Potential voluntary donors

This process enables identification of the most suitable donor.

HLA Tissue Typing Services

Analyzed Loci

HLA-A
HLA-B
HLA-C
HLA-DR
HLA-DQ

All analyses are conducted at the DNA level.

Methods Used

PCR-SSO Low Resolution methodology

If a suitable donor cannot be identified through low-resolution typing, high-resolution analyses are performed through accredited external laboratories to ensure uninterrupted transplantation processes.

Immunophenotyping by Flow Cytometry

The Gold Standard in Hematologic Diagnosis and Monitoring

Flow cytometry allows simultaneous analysis of cellular surface and cytoplasmic markers and is indispensable in hematologic malignancy diagnosis and follow-up.

Applications include:

Acute and chronic leukemias
Lymphomas
Other hematologic malignancies

Approximately 40 immunophenotypic panels are utilized to provide patient-specific analyses.

Minimal Residual Disease (MRD) Monitoring

Sensitive Assessment of Treatment Response

In leukemia patients, detection of minimal residual disease after treatment is critical for evaluating prognosis and relapse risk.

Our laboratory performs:

Patient-specific immunophenotypic marker–based analyses
Minimal Residual Disease (MRD) monitoring

MRD assessment guides treatment response evaluation and therapeutic decision-making.

Diagnostic Capabilities

Leukemia and Lymphoma Diagnostic Support

Diagnosis of myeloid and lymphoid leukemias via immunophenotyping
MRD monitoring based on individualized immunophenotypic profiles
Analysis of clinical specimens including:
- Bone marrow
- Tissue biopsies
- Synovial fluid
- Bronchoalveolar lavage
- Cerebrospinal fluid

Evaluation of Immunodeficiency Disorders

Flow cytometric analyses evaluate:

T lymphocytes
B lymphocytes
Natural Killer (NK) cells
Cellular subset distributions

When indicated, naïve and memory T-cell populations are assessed in detail.

Platelet Function Disorders

Glanzmann thrombasthenia
Bernard–Soulier syndrome
Collagen receptor defects

Hematopoietic Stem Cell Transplantation Support

During bone marrow transplantation, apheresis products are analyzed to determine:

Hematopoietic Stem and Progenitor Cell (HSPC) subsets
Cellular composition and proportions

These data assist clinical teams in optimizing transplantation timing and outcomes.

Scientific Excellence and Reliable Results

Our laboratory delivers accurate, rapid, and reliable results for transplantation and hematologic disease management. With high-quality standards, advanced technologies, and experienced specialists, we provide comprehensive support for complex immunologic evaluations.

Call us for detailed information and appointments

+90 (312) 666 7 666

Türkan PATIROĞLU

Who is undefined Türkan PATIROĞLU?

Türkan PATIROĞLU